Lesser Celandine spreads very rapidly, and typically is found on stream banks in areas that flood frequently. The rushing water spreads seeds as more mature plants continue to grow up the stream bank. Lesser Celandine can completely cover a flood zone in a thick mat that excludes all riparian and bankside native species. And because it emerges earlier than most native plants, it further inhibits the development of smaller Spring ephemerals, like bloodroot and trilliums.

As of July, 2024, Lesser Celandine is on the state of Michigan’s watch list for invasive species, meaning that it poses an immediate and significant threat to Michigan's natural resources.